Hypothalamic neurons implicated in energy homeostasis (Agrp, POMC, orexin, MCH) display fast, nutrient-independent dynamics. They do not simply mirror the slowly changing internal nutrient levels, but adapt rapidly to diverse external cues. Moreover, instead of eating, neonatal Agrp cells stimulate mother-attracting vocalisations, illustrating heuristic energy control beyond nutrient sensing or dietary self-control.
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