Epigenetic Modification in Coronary Atherosclerosis: JACC Review Topic of the Week

Barbara Rizzacasa; Francesca Amati; Francesco Romeo; Giuseppe Novelli; Jawahar L Mehta

doi:10.1016/j.jacc.2019.07.043

Epigenetic Modification in Coronary Atherosclerosis: JACC Review Topic of the Week

J Am Coll Cardiol. 2019 Sep 10;74(10):1352-1365. doi: 10.1016/j.jacc.2019.07.043.

Authors

Barbara Rizzacasa¹, Francesca Amati², Francesco Romeo³, Giuseppe Novelli⁴, Jawahar L Mehta⁵

Affiliations

¹ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
² Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; Department of Human Sciences and Quality of Life Promotion, University San Raffaele, Rome, Italy.
³ Complex Operative Unit of Cardiology, Policlinico Tor Vergata, Rome, Italy; Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
⁴ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; Neuromed IRCCS, Pozzilli, Italy; Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, Arkansas.
⁵ Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address: MehtaJL@uams.edu.

PMID: 31488273
DOI: 10.1016/j.jacc.2019.07.043

Abstract

Coronary artery disease (CAD) and its major complication, acute myocardial infarction (AMI), are the leading causes of disability and death worldwide. An individual's risk of developing CAD and MI is modulated by an interplay between genetic and lifestyle factors. It is now clear that epigenetics may play a central role in the development of CAD because epigenetic patterns are affected by the environment and can modulate gene expression. Here, the authors discuss the major epigenetic changes that contribute to CAD and the latest discoveries on the influence of the environment on epigenetic profiles in the development of CAD.

Keywords: coronary artery disease; long noncoding RNA; methylation; microRNA; myocardial infarction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Coronary Artery Disease* / epidemiology
Coronary Artery Disease* / genetics
DNA Methylation
Epigenesis, Genetic / genetics*
Gene-Environment Interaction
Humans
Risk Factors