Microglia Metabolic Breakdown Drives Alzheimer's Pathology

F Chris Bennett; Shane A Liddelow

doi:10.1016/j.cmet.2019.08.017

Microglia Metabolic Breakdown Drives Alzheimer's Pathology

Cell Metab. 2019 Sep 3;30(3):405-406. doi: 10.1016/j.cmet.2019.08.017.

Authors

F Chris Bennett¹, Shane A Liddelow²

Affiliations

¹ Department of Psychiatry, University of Pennsylvania Perelman School of Medicine and the Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: frederick.bennett@pennmedicine.upenn.edu.
² Neuroscience Institute, NYU School of Medicine, New York, NY, USA; Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY, USA. Electronic address: shane.liddelow@nyulangone.org.

PMID: 31484050
DOI: 10.1016/j.cmet.2019.08.017

Abstract

Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with amyloid beta acutely, and breakdown in both pathways chronically.

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MeSH terms

Alzheimer Disease*
Amyloid beta-Peptides
Brain
Humans
Microglia

Substances

Amyloid beta-Peptides