Single-Layer β Sheets as Versatile Protein-Binding Modules

Sally Esmail; Shawn S-C Li

doi:10.1016/j.str.2019.08.007

Single-Layer β Sheets as Versatile Protein-Binding Modules

Structure. 2019 Sep 3;27(9):1352-1354. doi: 10.1016/j.str.2019.08.007.

Authors

Sally Esmail¹, Shawn S-C Li²

Affiliations

¹ Department of Biochemistry, Western University, London, ON N6G 2V4, Canada.
² Department of Biochemistry, Western University, London, ON N6G 2V4, Canada; Department of Chemistry, Western University, London, ON N6G 2V4, Canada; Department of Oncology, Western University, London, ON N6G 2V4, Canada. Electronic address: sli@uwo.ca.

PMID: 31484049
DOI: 10.1016/j.str.2019.08.007

Abstract

In this issue of Structure, Li et al. (2019) describe the structure of the MORN4-Myo3a complex, revealing that the MORN repeats in MORN4 form a single-layer antiparallel β sheet and employs an extensive surface area in binding Myo3a. Their findings suggest that single-layer β sheets are versatile protein-binding modules.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Protein Binding
Protein Conformation, beta-Strand
Protein Structure, Secondary
Proteins*

Substances

Proteins

Grants and funding

CIHR/Canada