Pediatric SJS/TEN Subdued by a Combination of Dexamethasone, Cyclosporine, and Etanercept

J Cutan Med Surg. 2019 Sep/Oct;23(5):547-550. doi: 10.1177/1203475419861078.

Abstract

We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epidermolysis without immediate or late onset complications.

Keywords: dermatology; drug reaction; pediatric.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use*
  • Carbamazepine / adverse effects
  • Cyclosporine / therapeutic use*
  • Dexamethasone / therapeutic use*
  • Drug Therapy, Combination
  • Etanercept / therapeutic use*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Stevens-Johnson Syndrome / drug therapy*
  • Stevens-Johnson Syndrome / etiology

Substances

  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • Carbamazepine
  • Dexamethasone
  • Cyclosporine
  • Etanercept