MiR-1193 was sponged by LINC00963 and inhibited cutaneous squamous cell carcinoma progression by targeting SOX4

Abstract

Cutaneous squamous cell carcinoma (CSCC), a class of skin tumor derived from epidermal keratinocyte, is reputed as one of the most malignant tumors globally. MicroRNAs (miRNAs) are increasingly identified as essential players in CSCC. Current study aimed to uncover the impact and mechanism of miR-1193 in CSCC. We identified the low expression of miR-1193 in CSCC cell lines. Gain- and loss-of-function assays showed that miR-1193 acted as an inhibitor of proliferation and migration in CSCC cells. Furthermore, we illustrated that miR-1193 targeted and inhibited SRY-box 4 (SOX4), and that long intergenic non-protein coding RNA 963 (LINC00963) sponged miR-1193 to upregulate SOX4 expression. Rescue assays showed that LINC00963 regulated CSCC progression through miR-1193/SOX4 axis. In conclusion, our study firstly revealed the LINC00963/miR-1193/SOX4 axis in CSCC, indicating miR-1193 as a promising biological target in CSCC progression.

Keywords: Cutaneous squamous cell carcinoma; LINC00963; SOX4; miR-1193.