Anti-inflammatory phenylpropanoid glycosides from the fruits of Forsythia suspensa

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126635. doi: 10.1016/j.bmcl.2019.126635. Epub 2019 Aug 23.

Abstract

Five new phenylpropanoid glycosides, susaroysides A-E (1-5) were isolated from the fruits of Forsythia suspensa. Their structures were elucidated by comprehensive spectroscopic data analysis. The absolute configurations of their sugars were determined by GC analysis. Notably, susaroysides A-D possessed a sugar with an unsubstituted anomeric carbon, which is relatively rare in natural sources. Compound 1 exhibited significant anti-inflammatory activity against the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α expression in macrophage cells with the IC50 value of 1.053 μM.

Keywords: Anti-inflammatory activity; Forsythia suspensa; Phenylpropanoid glycosides; Susaroysides A–E; TNF-α.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / pharmacology*
  • Forsythia / chemistry*
  • Fruit / chemistry*
  • Glycosides / pharmacology*
  • Humans
  • Lipopolysaccharides / pharmacology
  • Macrophages / cytology
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Phenols / chemistry
  • Plant Extracts / pharmacology*
  • Propanols / chemistry
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Anti-Inflammatory Agents
  • Glycosides
  • Lipopolysaccharides
  • Phenols
  • Plant Extracts
  • Propanols
  • Tumor Necrosis Factor-alpha