On the diagnostic discrimination ability of mouthrinse and salivary aMMP-8 point-of-care testing regarding periodontal health and disease

Ismo T Räisänen; Anna Maria Heikkinen; Solomon O Nwhator; Kehinde A Umeizudike; Taina Tervahartiala; Timo Sorsa

doi:10.1016/j.diagmicrobio.2019.114871

On the diagnostic discrimination ability of mouthrinse and salivary aMMP-8 point-of-care testing regarding periodontal health and disease

Diagn Microbiol Infect Dis. 2019 Dec;95(4):114871. doi: 10.1016/j.diagmicrobio.2019.114871. Epub 2019 Jul 26.

Authors

Ismo T Räisänen¹, Anna Maria Heikkinen², Solomon O Nwhator³, Kehinde A Umeizudike⁴, Taina Tervahartiala², Timo Sorsa⁵

Affiliations

¹ Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63, (Haartmaninkatu 8), FI-00014, Helsinki, Finland. Electronic address: ismo.raisanen@helsinki.fiismo.raisanen@helsinki.fi.
² Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63, (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
³ Department of Preventive & Community Dentistry, Faculty of Dentistry, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
⁴ Department of Preventive Dentistry, Faculty of Dental Sciences, College of Medicine, University of Lagos, Idi-araba, Lagos, Nigeria.
⁵ Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63, (Haartmaninkatu 8), FI-00014, Helsinki, Finland; Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm SE-171 77, Sweden.

PMID: 31473032
DOI: 10.1016/j.diagmicrobio.2019.114871

Abstract

This study investigated the diagnostic utility of mouthrinse and saliva in aMMP-8 measurements to analyze patients' risk for active periodontal tissue destruction and progression of periodontal disease among 47 adolescents. Results show that measurements from mouthrinse produce better discrimination and should be used instead of saliva measurements.

Keywords: Biomarkers; Matrix metalloproteinase 8; Mouthrinse; Periodontitis; Point-of-care testing; Saliva.

Publication types

Comparative Study

MeSH terms

Adolescent
Biomarkers / analysis
Gingival Crevicular Fluid / enzymology
Humans
Matrix Metalloproteinase 8 / analysis*
Mouthwashes*
Oral Health
Periodontal Diseases / diagnosis*
Periodontal Diseases / enzymology
Point-of-Care Testing*
Saliva / enzymology
Specimen Handling / standards

Substances

Biomarkers
Mouthwashes
Matrix Metalloproteinase 8