Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis

Chin J Nat Med. 2019 Aug;17(8):624-630. doi: 10.1016/S1875-5364(19)30065-2.

Abstract

Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5 ± 2.4 and 77.3 ± 2.5 μmol·L-1, respectively. Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6 ± 2.1 μmol·L-1.

Keywords: Cytotoxicity; Furostanol saponins; Liliaceae; Tupistra chinensis.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Hep G2 Cells
  • Humans
  • Inhibitory Concentration 50
  • Liliaceae / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry
  • Rhizome / chemistry
  • Saponins / chemistry*
  • Saponins / pharmacology
  • Sterols / chemistry*
  • Sterols / pharmacology

Substances

  • Antineoplastic Agents
  • Plant Extracts
  • Saponins
  • Sterols