Synthesis, characterization and applications of copper(II) complexes with Schiff bases derived from chitooligosaccharide and iodosubstituted salicylaldehyde

Yi-An Wang; Ting Liu; Guo-Qing Zhong

doi:10.1016/j.carbpol.2019.115151

Synthesis, characterization and applications of copper(II) complexes with Schiff bases derived from chitooligosaccharide and iodosubstituted salicylaldehyde

Carbohydr Polym. 2019 Nov 15:224:115151. doi: 10.1016/j.carbpol.2019.115151. Epub 2019 Aug 5.

Authors

Yi-An Wang¹, Ting Liu¹, Guo-Qing Zhong²

Affiliations

¹ School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan 621010, PR China.
² School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan 621010, PR China. Electronic address: zgq316@163.com.

PMID: 31472824
DOI: 10.1016/j.carbpol.2019.115151

Abstract

Cu(II) complexes with Schiff bases derived from chitooligosaccharide and iodosubstituted salicylaldehyde (I-SCOS) were synthesized and characterized by EA, ICP, FTIR and SEM. The Cu(II) was coordinated by the imino N atoms and phenolic hydroxyl O atoms from I-SCOS. The antimicrobial activities of I-SCOS and their Cu(II) complexes were investigated against Enterobacter cloacae, Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus saprophyticus. The results indicated that the introduction of the iodosubstituted and the imine groups of Schiff bases increased the antimicrobial activity of I-SCOS and exhibited a superposition effect of molecular structure. The coordination interaction between I-SCOS and Cu(II) further enhanced the antimicrobial activities. The scavenging superoxide anion radical activity of I-SCOS derivatives was estimated by using NBT/VB₂/methionine superoxide anion radical producing system. When the concentration of the complexes was more than 0.3 mg/mL, their antioxidant activity was higher than that of I-SCOS.

Keywords: Antibacterial activity; Antioxidant function; Chitooligosaccharide; Copper complex; Iodine-containing Schiff base.