Plasmonic gold nanoparticles: Optical manipulation, imaging, drug delivery and therapy

Majid Sharifi; Farnoosh Attar; Ali Akbar Saboury; Keivan Akhtari; Nasrin Hooshmand; Anwarul Hasan; Mostafa A El-Sayed; Mojtaba Falahati

doi:10.1016/j.jconrel.2019.08.032

Plasmonic gold nanoparticles: Optical manipulation, imaging, drug delivery and therapy

J Control Release. 2019 Oct:311-312:170-189. doi: 10.1016/j.jconrel.2019.08.032. Epub 2019 Aug 28.

Authors

Majid Sharifi¹, Farnoosh Attar², Ali Akbar Saboury³, Keivan Akhtari⁴, Nasrin Hooshmand⁵, Anwarul Hasan⁶, Mostafa A El-Sayed⁷, Mojtaba Falahati⁸

Affiliations

¹ Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
² Department of Biology, Faculty of Food Industry & Agriculture, Standard Research Institute, Karaj, Iran.
³ Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
⁴ Department of Physics, University of Kurdistan, Sanandaj, Iran.
⁵ Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, United States.
⁶ Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar; Biomedical Research Center, Qatar University, Doha 2713, Qatar. Electronic address: ahasan@qu.edu.qa.
⁷ Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, United States. Electronic address: melsayed@gatech.edu.
⁸ Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: mojtaba.falahati@alumni.ut.ac.ir.

PMID: 31472191
DOI: 10.1016/j.jconrel.2019.08.032

Abstract

Over the past two decades, the development of plasmonic nanoparticle (NPs), especially gold (Au) NPs, is being pursued more seriously in the medical fields such as imaging, drug delivery, and theranostic systems. However, there is no comprehensive review on the effect of the physical and chemical parameters of AuNPs on their plasmonic properties as well as the use of these unique characteristic in medical activities such as imaging and therapeutics. Therefore, in this literature the surface plasmon resonance (SPR) modeling of AuNPs was accurately captured toward precision medicine. Indeed, we investigated the importance of plasmonic properties of AuNPs in optical manipulation, imaging, drug delivery, and photothermal therapy (PTT) of cancerous cells based on their physicochemical properties. Finally, some challenges regarding the commercialization of AuNPs in future medicine such as, cytotoxicity, lack of standards for medical applications, high cost, and time-consuming process were discussed.

Keywords: Drug delivery; Imaging; Optical manipulation; Photothermal therapy; Plasmonic gold nanoparticle.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Diagnostic Imaging
Drug Delivery Systems
Gold / administration & dosage*
Humans
Metal Nanoparticles / administration & dosage*
Neoplasms / diagnostic imaging
Neoplasms / therapy
Optical Phenomena
Phototherapy

Substances

Gold