Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment

Hua-Yang Fan; Xiang-Hua Yu; Ke Wang; Yi-Jia Yin; Ya-Jie Tang; Ya-Ling Tang; Xin-Hua Liang

doi:10.1016/j.ejmech.2019.111620

Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment

Eur J Med Chem. 2019 Nov 15:182:111620. doi: 10.1016/j.ejmech.2019.111620. Epub 2019 Aug 12.

Authors

Hua-Yang Fan¹, Xiang-Hua Yu¹, Ke Wang¹, Yi-Jia Yin², Ya-Jie Tang³, Ya-Ling Tang⁴, Xin-Hua Liang⁵

Affiliations

¹ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China.
² State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China.
³ State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; Hubei Key Laboratory of Industrial Microbiology, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, 430068, China. Electronic address: yajietang@qq.com.
⁴ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China. Electronic address: tangyaling@scu.edu.cn.
⁵ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China. Electronic address: lxh88866@scu.edu.cn.

PMID: 31470307
DOI: 10.1016/j.ejmech.2019.111620

Abstract

Graphene quantum dots (GQDs) as novel nanomaterials, have received significant interest in the field of biomedical applications. It is worth noting that a large amount of research is devoted to GQDs-based nanocomposites for cancer treatment, especially for photodynamic therapy (PDT), in that they can act not only as more favorable photosensitizers (PSs) but also nanoplatforms for delivering PSs. In this review, the biological behavior and physicochemical properties of GQDs for PDT are described in detail, and the application of GQDs-based nanocomposites in improved PDT and PDT-based combination therapies is analyzed, which may provide a new strategy for designing efficient PDT systems for cancer treatment.

Keywords: Cancer therapy; Drug delivery; Graphene quantum dots; Nanomaterials; Photodynamic therapy.

Publication types

Review

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Drug Carriers / chemistry
Graphite / chemistry*
Humans
Nanoparticles / chemistry*
Neoplasms / drug therapy*
Photochemotherapy*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Quantum Dots / chemistry*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Drug Carriers
Photosensitizing Agents
Graphite