Co-occurrence of BCR-ABL1 rearrangement and CALR mutation in a single leukemic stem cell: evidence that BCR-ABL1 oncogenic addiction prevails over CALR signaling

Leuk Lymphoma. 2020 Jan;61(1):209-212. doi: 10.1080/10428194.2019.1658101. Epub 2019 Aug 29.

Authors

Estelle Balducci^{1

2}, Safa Sanekli^{1

3}, Patricia Hugues¹, Mathis Soubeyrand¹, Claire Borie², Xavier Fund², Christophe Desterke^{1

2}, Cédric Aumont³, Jamila Faivre^{2

4}, Annelise Bennaceur-Griscelli^{1

2

3

5}, Ali G Turhan^{1

2

3

5}

Affiliations

¹ INSERM, Unité Mixte de Recherche (UMR) 935, Villejuif, France.
² Assistance Publique-Hôpitaux de Paris, Service D'Hématologie, Hôpital Paul Brousse, Villejuif, France.
³ Assistance Publique-Hôpitaux de Paris, Service D'Hématologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
⁴ INSERM, UMR 785, Centre Hépato-Biliaire, Villejuif, France.
⁵ INGESTEM-ESteam Pluripotent Stem Cell Infrastructure, Villejuif, France.

PMID: 31464171
DOI: 10.1080/10428194.2019.1658101

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged
Female
Fusion Proteins, bcr-abl* / genetics
Gene Rearrangement
Humans
Leukemia / genetics*
Mutation
Neoplastic Stem Cells
Oncogene Addiction*

Substances

Fusion Proteins, bcr-abl