Suzuki Cross-Coupling of [2.2]Paracyclophane Trifluoroborates with Pyridyl and Pyrimidyl Building Blocks

Daniel M Knoll; Stefan Bräse

doi:10.1021/acsomega.8b01774

Suzuki Cross-Coupling of [2.2]Paracyclophane Trifluoroborates with Pyridyl and Pyrimidyl Building Blocks

ACS Omega. 2018 Sep 27;3(9):12158-12162. doi: 10.1021/acsomega.8b01774. eCollection 2018 Sep 30.

Authors

Daniel M Knoll¹, Stefan Bräse^{1

2}

Affiliations

¹ Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
² Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany.

Abstract

We report a new Suzuki cross-coupling protocol for high yielding derivatization of [2.2]paracyclophane with pyridyl and pyrimidyl substituents. The [2.2]paracyclophane trifluoroborate salt presented herein is a bench stable, easily accessible, and convenient substitute to former cross-coupling substrates. This will be of very high interest for future paracyclophane derivatization endeavors.