Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

J Int Med Res. 2019 Oct;47(10):5289-5293. doi: 10.1177/0300060519869133. Epub 2019 Aug 28.

Abstract

Primary thyroid lymphoma (PTL) is a very rare type of thyroid malignant tumor. PTL coexisting with papillary thyroid carcinoma (PTC) is even scarcer and can be easily overlooked. We present our experience of the diagnosis and treatment of a 37-year-old woman with primary thyroid diffuse large B cell lymphoma complicated with PTC. We also considered this case in the context of previous reports. The results indicated that the incidence of concurrent Hashimoto’s disease varied among patients with different lymphoma subtypes, with the highest incidence in patients with mucosa-associated lymphoid tissue lymphoma. Furthermore, thyroid cancer and thus the combination of PTL and PTC were more common in women.

Keywords: Coexistence; Hashimoto’s disease; mucosa-associated lymphoid tissue lymphoma; papillary thyroid carcinoma; primary thyroid diffuse large B cell lymphoma; primary thyroid lymphoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Female
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / classification
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Thyroid Cancer, Papillary / pathology*
  • Thyroid Neoplasms / pathology*