Current State of Platinum Complexes for the Treatment of Advanced and Drug-Resistant Breast Cancers

Adv Exp Med Biol. 2019:1152:253-270. doi: 10.1007/978-3-030-20301-6_13.

Abstract

Breast cancer represents the major cause of death in female cancer patients. New efficient treatments are desperately needed, particularly especially for patients suffering from advanced stages and metastases, or those who are no longer responding to the clinically established drugs such as cisplatin or carboplatin. New promising therapy regimens and platinum complexes have emerged over the last few years that displayed efficacy in advanced platinum- and/or drug-resistant breast tumors and metastases. This chapter provides an overview of the latest developments in the field of platinum-based drugs against advanced and resistant breast cancers since 2013.

Keywords: Anticancer agents; Breast cancer; Metastasis; Multidrug resistance (MDR); Platinum complexes; Triple-negative breast cancer (TNBC).

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Breast Neoplasms / drug therapy*
  • Carboplatin
  • Cisplatin
  • Drug Resistance, Neoplasm*
  • Female
  • Humans
  • Platinum Compounds / therapeutic use*

Substances

  • Antineoplastic Agents
  • Platinum Compounds
  • Carboplatin
  • Cisplatin