Intercellular communication in the innate immune system through the cGAS-STING pathway

Ramya Nandakumar; Samuel Joseph Windross; Søren R Paludan

doi:10.1016/bs.mie.2019.07.007

Intercellular communication in the innate immune system through the cGAS-STING pathway

Methods Enzymol. 2019:625:1-11. doi: 10.1016/bs.mie.2019.07.007. Epub 2019 Jul 23.

Authors

Ramya Nandakumar¹, Samuel Joseph Windross¹, Søren R Paludan²

Affiliations

¹ Department of Biomedicine, University of Aarhus, Aarhus, Denmark; Aarhus Research Center for Innate Immunology, University of Aarhus, Aarhus, Denmark.
² Department of Biomedicine, University of Aarhus, Aarhus, Denmark; Aarhus Research Center for Innate Immunology, University of Aarhus, Aarhus, Denmark. Electronic address: srp@biomed.au.dk.

PMID: 31455521
DOI: 10.1016/bs.mie.2019.07.007

Abstract

Type I interferons (IFNα/β) are pivotal to anti-viral defense. Although an absolute requirement for viral clearance, the presence of IFN in high doses sustained over time has been implicated to be the underlying cause of clinical outcomes such as interferonopathies. Therefore, tight regulation of cellular communication processes is required for tissue homeostasis. This review covers the cellular signaling pathways initiated by DNA sensing through cGAS in the cellular cytosol, with particular focus on the subsequent establishment of immune responses in bystander cells.

Keywords: Cell-cell interactions; Extracellular vesicles; Innate immunity; Interferon.

Publication types

Review

MeSH terms

Animals
Cell Communication / genetics
Cell Communication / physiology*
Extracellular Vesicles / metabolism
Humans
Immunity, Innate / genetics
Immunity, Innate / physiology*
Interferons / metabolism*
Membrane Proteins / genetics
Membrane Proteins / metabolism
Nucleotidyltransferases / genetics
Nucleotidyltransferases / metabolism

Substances

Membrane Proteins
Interferons
Nucleotidyltransferases