Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System

Sophie Lalande; Troy J Cross; Manda L Keller-Ross; Norman R Morris; Bruce D Johnson; Bryan J Taylor

doi:10.1249/JES.0000000000000208

Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System

Exerc Sport Sci Rev. 2020 Jan;48(1):11-19. doi: 10.1249/JES.0000000000000208.

Authors

Sophie Lalande¹, Troy J Cross, Manda L Keller-Ross², Norman R Morris³, Bruce D Johnson⁴, Bryan J Taylor⁵

Affiliations

¹ Department of Kinesiology and Heath Education, The University of Texas at Austin, Austin, TX.
² Divisions of Physical Therapy and Rehabilitation Sciences, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN.
³ School of Physiotherapy and Exercise Science, Griffith University, Queensland, Australia.
⁴ Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
⁵ School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Abstract

We propose that abnormalities of the pulmonary system contribute significantly to the exertional dyspnea and exercise intolerance observed in patients with chronic heart failure. Interventions designed to address the deleterious pulmonary manifestations of heart failure may, therefore, yield promising improvements in exercise tolerance in this population.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Pressure / physiology
Bronchi / blood supply
Chronic Disease
Dyspnea / physiopathology
Exercise Tolerance / physiology*
Heart Failure / physiopathology*
Hemodynamics / physiology*
Humans
Hypertension, Pulmonary / physiopathology
Lung / blood supply
Lung / physiopathology*
Muscle, Skeletal / physiopathology
Oxygen Consumption / physiology
Prognosis
Pulmonary Diffusing Capacity
Pulmonary Gas Exchange
Ventilation-Perfusion Ratio
Work of Breathing / physiology

Grants and funding

R01 HL071478/HL/NHLBI NIH HHS/United States