Diabetes insipidus and acute myeloid leukemia harboring monosomy 7: report of two cases and literature review

Acta Clin Belg. 2021 Apr;76(2):132-135. doi: 10.1080/17843286.2019.1660024. Epub 2019 Aug 27.

Abstract

Acute myeloid leukemia (AML) is unusually associated with diabetes insipidus (DI) in patients bearing monosomy 7 or chromosome 3 aberrations. To date, 84 cases have been reported worldwide. Physiopathological mechanisms linking these chromosomal abnormalities to DI are not yet understood. We report two patients with AML/DI and review the medical literature on those conditions.

Keywords: Diabetes insipidus; acute myeloid leukemia; monosomy 7.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Chromosome Deletion
  • Chromosomes, Human, Pair 7
  • Diabetes Insipidus* / genetics
  • Diabetes Mellitus*
  • Humans
  • Leukemia, Myeloid, Acute* / genetics

Supplementary concepts

  • Chromosome 7, monosomy