Computational Fluid Dynamics Analysis of Lateral Striate Arteries in Acute Ischemic Stroke Using 7T High-resolution Magnetic Resonance Angiography

Futoshi Mori; Fujimaro Ishida; Tatsunori Natori; Haruna Miyazawa; Hiroyuki Kameda; Taisuke Harada; Kunihiro Yoshioka; Fumio Yamashita; Ikuko Uwano; Kenji Ito; Makoto Sasaki

doi:10.1016/j.jstrokecerebrovasdis.2019.104339

Computational Fluid Dynamics Analysis of Lateral Striate Arteries in Acute Ischemic Stroke Using 7T High-resolution Magnetic Resonance Angiography

J Stroke Cerebrovasc Dis. 2019 Nov;28(11):104339. doi: 10.1016/j.jstrokecerebrovasdis.2019.104339. Epub 2019 Aug 24.

Authors

Affiliations

¹ Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate Prefecture, Japan. Electronic address: fumori@iwate-med.ac.jp.
² Department of Neurosurgery, Mie Chuo Medical Center, Mie Prefecture, Japan.
³ Department of Neurology and Gerontology, Iwate Medical University, Iwate Prefecture, Japan.
⁴ Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Japan.
⁵ Department of Radiology, Iwate Medical University, Iwate Prefecture, Japan.
⁶ Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate Prefecture, Japan.

PMID: 31451338
DOI: 10.1016/j.jstrokecerebrovasdis.2019.104339

Abstract

Background: Infarcts in the lateral striate artery (LSA) territory can be caused by several pathological changes, including lipohyalinosis and microatheroma. However, fluid dynamic effects on these changes remain unknown. Thus, we investigated whether the fluid dynamic metrics of the LSAs were altered in patients with acute ischemic stroke using computational fluid dynamics (CFD) analysis.

Methods: Fifty-one patients with acute ischemic stroke confined in the basal ganglia and/or corona radiata underwent high-resolution magnetic resonance angiography (HR-MRA) at 7T. We performed CFD analyses to obtain indices including the wall shear stress (WSS), WSS gradient (WSSG), and flow velocity (FV) and compared these values between the ipsilesional and contralesional sides in the patients with infarcts in the LSA or non-LSA territories.

Results: In patients with LSA-territory infarcts, the WSS, WSSG, and FV values were significantly lower in the ipsilesional LSAs than in the contralesional LSAs (P = .01-.03), while these values in the proximal middle cerebral arteries showed no significant lateralities. In contrast, in patients with non-LSA-territory infarcts, there were no significant lateralities in the metrics between the ipsilesional and contralesional sides.

Conclusions: The CFD analyses using HR-MRA revealed significantly low WSS and WSSG values of the ipsilesional LSAs compared with that of the contralesional side in patients with LSA-territory infarcts, suggesting that fluid dynamic factors of LSAs can be one of the risk factors for LSA-territory infarctions.

Keywords: Lateral striate artery; acute stroke; computational fluid dynamics; magnetic resonance angiography; ultrahigh field.

MeSH terms

Adult
Aged
Aged, 80 and over
Blood Flow Velocity
Brain Ischemia / diagnostic imaging*
Brain Ischemia / physiopathology
Cerebral Angiography / methods*
Cerebral Arteries / diagnostic imaging*
Cerebral Arteries / physiopathology
Cerebrovascular Circulation*
Female
Humans
Magnetic Resonance Angiography*
Male
Middle Aged
Models, Cardiovascular*
Patient-Specific Modeling*
Predictive Value of Tests
Prospective Studies
Stress, Mechanical
Stroke / diagnostic imaging*
Stroke / physiopathology