Synthesis of Four Illudalane Sesquiterpenes Utilizing a One-Pot Diels-Alder/Oxidative Aromatization Sequence

Org Lett. 2019 Sep 6;21(17):6879-6883. doi: 10.1021/acs.orglett.9b02511. Epub 2019 Aug 23.

Abstract

The concise, divergent total syntheses of four illudalane sesquiterpenes using an indanone as the key intermediate are reported. The key elements in these total syntheses, which involve only four to six operational steps, consist of a Suzuki cross-coupling and a one-pot Diels-Alder/oxidative aromatization reaction.

Publication types

  • Research Support, Non-U.S. Gov't