Single fraction urethra-sparing prostate cancer SBRT: Phase I results of the ONE SHOT trial

Radiother Oncol. 2019 Oct:139:83-86. doi: 10.1016/j.radonc.2019.07.018. Epub 2019 Aug 17.

Abstract

The ONE SHOT trial is the first phase I/II prospective, multicenter, single-arm study assessing the efficacy and safety of a single-dose SBRT for men with localized prostate cancer. Aim of this paper is to present the phase I results of a 19 Gy single fraction urethra-sparing SBRT with real-time electromagnetic tracking.

Keywords: Monotherapy; Phase I/II trial; Prostate cancer; SBRT; Toxicity.

Publication types

  • Clinical Trial, Phase I
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Humans
  • Male
  • Prospective Studies
  • Prostatic Neoplasms / radiotherapy*
  • Radiosurgery / methods*
  • Radiotherapy, Image-Guided / methods*
  • Urethra / radiation effects*