For Viral Reservoir Studies, Timing Matters

Bethany A Horsburgh; Sarah Palmer

doi:10.1016/j.tim.2019.08.003

For Viral Reservoir Studies, Timing Matters

Trends Microbiol. 2019 Oct;27(10):809-810. doi: 10.1016/j.tim.2019.08.003. Epub 2019 Aug 17.

Authors

Bethany A Horsburgh¹, Sarah Palmer²

Affiliations

¹ Centre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, New South Wales, 2145, Australia; Sydney Medical School, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2006, Australia.
² Centre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, New South Wales, 2145, Australia; Sydney Medical School, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2006, Australia. Electronic address: sarah.palmer@sydney.edu.au.

PMID: 31431318
DOI: 10.1016/j.tim.2019.08.003

Abstract

New strategies to eliminate persistent HIV-1 during therapy will benefit from animal models, such as non-human primates infected with simian immunodeficiency viruses (SIV) or chimeras (SHIV). Understanding the genetic composition of SIV and SHIV reservoirs during therapy is therefore crucial for the future application of this model.

Keywords: HIV; SHIV; SIV; non-human primate models; reservoirs.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Genome, Viral
HIV Infections*
HIV-2
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome*
Simian Immunodeficiency Virus / genetics*

Grants and funding

UM1 AI126611/AI/NIAID NIH HHS/United States