Ultra-fast and probe-free cellulose biosensor for visual detection of Cu2+ ions in biological samples

R J Wang; L W Zhang; R Liu; L Liu; J M Yao

doi:10.1016/j.carbpol.2019.115117

Ultra-fast and probe-free cellulose biosensor for visual detection of Cu²⁺ ions in biological samples

Carbohydr Polym. 2019 Nov 1:223:115117. doi: 10.1016/j.carbpol.2019.115117. Epub 2019 Jul 23.

Authors

R J Wang¹, L W Zhang¹, R Liu¹, L Liu², J M Yao³

Affiliations

¹ The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Park, Hangzhou 310018, China.
² The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Park, Hangzhou 310018, China; National Engineering Laboratory of Textile Fiber Materials & Processing Technology, Hangzhou 310018, China. Electronic address: linliu@zstu.edu.cn.
³ The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Park, Hangzhou 310018, China; National Engineering Laboratory of Textile Fiber Materials & Processing Technology, Hangzhou 310018, China.

PMID: 31427014
DOI: 10.1016/j.carbpol.2019.115117

Abstract

Novel, portable, probe-free, liquid cellulose biosensor was explored via a facile one-pot process for Cu²⁺ ions detection by naked eyes. The as-prepared biosensor displayed specific recognition towards Cu²⁺ ions in aqueous solution, even in complex urine and serum samples within 10 s, showing fast response characteristic. There is barely any interference on the Cu²⁺ ions detection by other metal ions or other complex substances in urine and serum, and the corresponding detection limit is as low as 1.185, 1.9309 and 1.9154 ppm, respectively. Moreover, the cellulose biosensor could act as an excellent candidate to sense Cu²⁺ ions in biological samples including urine and serum from SD rats with satisfying accuracies and biocompatibility. This study exploits a potential application of cellulose in biosensing and monitoring related to Cu²⁺ ions.

Keywords: Cellulose biosensor; Copper ions; Fast response; Visual detection, biological samples.

MeSH terms

Animals
Biosensing Techniques*
Cattle
Cellulose / chemical synthesis
Cellulose / chemistry*
Copper / blood*
Copper / urine*
Hydrogen-Ion Concentration
Ions / analysis
Rats
Rats, Sprague-Dawley

Substances

Ions
Copper
Cellulose