Gastroschisis: State of the Art in Translating Experimental Research to the Bedside

Eur J Pediatr Surg. 2019 Aug;29(4):342-351. doi: 10.1055/s-0039-1694746. Epub 2019 Aug 19.

Abstract

The survival rate of newborns with gastroschisis (GS) has been increasing in the past decades; however, the morbidity continues to be high, mainly related to the length of hospitalization due to disturbances of motility, absorption, and risk of intestinal infections. The development of basic research with the creation of experimental models has provided enormous advances in the understanding of the pathophysiology of the disease. These models allowed the study of the target genes involved in the embryology of the defect, the influence of the amniotic fluid, and the use of drugs and fetal therapies in an attempt to reduce the intestinal damage and to provide a rapid return of intestinal motility. Our aim was to describe the main GS models and the translational, historical impact of these research advances on the disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Gastroschisis* / etiology
  • Gastroschisis* / physiopathology
  • Gastroschisis* / therapy
  • Humans
  • Translational Research, Biomedical / methods*