Comparison of Fatigue and Quality of Life in Individuals With Pancreatogenic Diabetes After Total or Partial Pancreatectomy

Oncol Nurs Forum. 2019 Sep 1;46(5):E159-E170. doi: 10.1188/19.ONF.E159-E170.

Abstract

Objectives: To compare fatigue and quality of life (QOL) between individuals with pancreatogenic diabetes after total pancreatectomy (TP) and pancreaticoduodenectomy (PD).

Sample & setting: 50 individuals (14 after TP and 36 after PD) were recruited from a pancreatic surgical outpatient department. A final sample of 39 matched individuals (13 after TP and 26 after PD) were included in the final analysis.

Methods & variables: A comparative cross-sectional approach was used. Variables were fatigue and QOL. The Fatigue Symptom Inventory and European Organisation for the Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30 were used. Data went through propensity score one-to-two matching. Generalized estimating equation was used to compare fatigue and QOL.

Results: The groups showed no statistically significant difference in fatigue intensity and overall QOL. The TP group had significantly longer fatigue duration, perceived higher interference of functioning, lower physical function, and a higher level of insomnia.

Implications for nursing: Future studies with a larger sample and longitudinal design will help identify the trajectory of fatigue and QOL in individuals with pancreatogenic diabetes post-TP and PD.

Keywords: fatigue; pancreaticoduodenectomy; quality of life; total pancreatectomy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Carcinoma, Pancreatic Ductal / complications*
  • Carcinoma, Pancreatic Ductal / psychology
  • Carcinoma, Pancreatic Ductal / surgery
  • Cross-Sectional Studies
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / psychology
  • Fatigue / etiology*
  • Female
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Middle Aged
  • Neuroendocrine Tumors / complications
  • Neuroendocrine Tumors / psychology
  • Neuroendocrine Tumors / surgery
  • Pancreatectomy / methods*
  • Pancreatic Neoplasms / complications*
  • Pancreatic Neoplasms / psychology
  • Pancreatic Neoplasms / surgery
  • Pancreatitis, Chronic / complications
  • Pancreatitis, Chronic / psychology
  • Pancreatitis, Chronic / surgery
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology*
  • Postoperative Complications / psychology
  • Propensity Score
  • Quality of Life*
  • Severity of Illness Index
  • Surveys and Questionnaires

Substances

  • Hypoglycemic Agents