Silencing TBX1 Exerts Suppressive Effects on Epithelial-Mesenchymal Transition and Inflammation of Chronic Rhinosinusitis Through Inhibition of the TGF β-Smad2/3 Signaling Pathway in Mice

Am J Rhinol Allergy. 2020 Jan;34(1):16-25. doi: 10.1177/1945892419866543. Epub 2019 Aug 18.

Authors

Yu Zhong¹, Yunqiu Li¹, Hua Zhang²

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha, P.R. China.
² Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, P.R. China.

PMID: 31422678
DOI: 10.1177/1945892419866543

No abstract available

Keywords: T-box 1; TGFβ-Smad2/3 signaling pathway; chronic rhinosinusitis; epithelial–mesenchymal transition; inflammation.

MeSH terms

Animals
Blotting, Western
Chronic Disease
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Epithelial-Mesenchymal Transition
Gene Expression Regulation*
Inflammation / genetics*
Inflammation / metabolism
Mice
Mice, Inbred C57BL
Nasal Mucosa / metabolism
Nasal Mucosa / pathology
RNA / genetics
Rhinitis / genetics*
Rhinitis / metabolism
Rhinitis / pathology
Signal Transduction
Sinusitis / genetics*
Sinusitis / metabolism
Sinusitis / pathology
Smad2 Protein / genetics*
Smad2 Protein / metabolism
T-Box Domain Proteins / biosynthesis
T-Box Domain Proteins / genetics*
Transforming Growth Factor beta / genetics*
Transforming Growth Factor beta / metabolism

Substances

Smad2 Protein
Smad2 protein, mouse
T-Box Domain Proteins
Tbx1 protein, mouse
Transforming Growth Factor beta
RNA