Stealth functionalization of biomaterials and nanoparticles by CD47 mimicry

Seyed Mohammad Gheibi Hayat; Vanessa Bianconi; Matteo Pirro; Amirhossein Sahebkar

doi:10.1016/j.ijpharm.2019.118628

Stealth functionalization of biomaterials and nanoparticles by CD47 mimicry

Int J Pharm. 2019 Oct 5:569:118628. doi: 10.1016/j.ijpharm.2019.118628. Epub 2019 Aug 14.

Authors

Seyed Mohammad Gheibi Hayat¹, Vanessa Bianconi², Matteo Pirro², Amirhossein Sahebkar³

Affiliations

¹ Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
² Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Italy.
³ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir.

PMID: 31421198
DOI: 10.1016/j.ijpharm.2019.118628

Abstract

Polymeric biomaterials and nanoparticles (NPs) have shown a potential to be widely used for medical purposes. Functional limits of their biocompatibility depend on cellular and molecular responses between host and their artificial surfaces. Accordingly, medical devices of polymer biomaterials like endovascular stents, cardiopulmonary bypass circuits, and prostheses, may trigger inflammation or can be rejected by host due to the induction of immune responses. Furthermore, the main restriction to the use of NPs for medical purposes is their short in vivo circulation time because of their rapid clearance via the reticuloendothelial system. Various methods are under investigation to produce bioinert biomaterials and NPs. Currently, PEGylation and camouflaging are the most common approaches to enhance their biocompatibility. However, the disadvantages and limitations of these methods are leading to research new strategies. The CD47 molecule is well known as a widely expressed cellular surface receptor activating the transudction of the ''don't-eat-me'' signal. This review elaborates on the role of CD47 in the immune system and the application of CD47 mimicry peptides to produce bioinert biomaterials and NPs.

Keywords: Biomimetic nanoparticles; CD47; Membrane-coated nanoparticle; PEGylation; Self-peptide.

Publication types

Review

MeSH terms

Animals
Biomimetic Materials* / administration & dosage
Biomimetic Materials* / chemistry
CD47 Antigen* / administration & dosage
CD47 Antigen* / chemistry
CD47 Antigen* / immunology
Humans
Nanoparticles* / administration & dosage
Nanoparticles* / chemistry
Phagocytosis

Substances

CD47 Antigen