A comprehensive characterization of chronic norovirus infection in immunodeficient hosts

Li-An K Brown; Christopher Ruis; Ian Clark; Sunando Roy; Julianne R Brown; Adriana S Albuquerque; Smita Y Patel; Joanne Miller; Mohammed Yousuf Karim; Samir Dervisevic; Jennifer Moore; Charlotte A Williams; Juliana Cudini; Fernando Moreira; Penny Neild; Suranjith L Seneviratne; Sarita Workman; Christos Toumpanakis; Claire Atkinson; Siobhan O Burns; Judith Breuer; David M Lowe

doi:10.1016/j.jaci.2019.07.036

A comprehensive characterization of chronic norovirus infection in immunodeficient hosts

J Allergy Clin Immunol. 2019 Nov;144(5):1450-1453. doi: 10.1016/j.jaci.2019.07.036. Epub 2019 Aug 13.

Authors

Li-An K Brown¹, Christopher Ruis², Ian Clark³, Sunando Roy⁴, Julianne R Brown⁵, Adriana S Albuquerque⁶, Smita Y Patel⁷, Joanne Miller⁸, Mohammed Yousuf Karim⁹, Samir Dervisevic¹⁰, Jennifer Moore¹⁰, Charlotte A Williams⁴, Juliana Cudini⁴, Fernando Moreira¹¹, Penny Neild¹², Suranjith L Seneviratne¹¹, Sarita Workman¹¹, Christos Toumpanakis¹³, Claire Atkinson⁶, Siobhan O Burns¹⁴, Judith Breuer⁴, David M Lowe¹⁵

Affiliations

¹ Department of Infectious Diseases, Royal Free London NHS Foundation Trust, London, United Kingdom; Department of Microbiology, Whittington Health NHS Trust, London, United Kingdom.
² Division of Infection and Immunity, University College London, London, United Kingdom; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Medical Research Council (MRC)-Laboratory of Molecular Biology, Cambridge, United Kingdom.
³ Department of Histopathology, Royal Free London NHS Foundation Trust, London, United Kingdom.
⁴ Division of Infection and Immunity, University College London, London, United Kingdom.
⁵ Department of Microbiology, Virology and Infection Prevention and Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
⁶ Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom.
⁷ Oxford University Hospitals NHS Trust and NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
⁸ Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, Surrey, United Kingdom.
⁹ Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, Surrey, United Kingdom; Pathology, Sidra Medicine, Doha, Qatar.
¹⁰ Norfolk and Norwich University Hospital, Norwich, Norfolk, United Kingdom.
¹¹ Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom.
¹² St George's University Hospitals NHS Foundation Trust, London, United Kingdom.
¹³ Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, United Kingdom.
¹⁴ Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom; Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom.
¹⁵ Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom; Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom. Electronic address: d.lowe@ucl.ac.uk.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, CD19 / metabolism
Antiviral Agents / therapeutic use
B-Lymphocytes / immunology*
Caliciviridae Infections / diagnosis
Caliciviridae Infections / drug therapy
Caliciviridae Infections / immunology*
Cells, Cultured
Common Variable Immunodeficiency / diagnosis
Common Variable Immunodeficiency / drug therapy
Common Variable Immunodeficiency / immunology*
Enterocolitis
Female
Humans
Immunocompromised Host*
Male
Middle Aged
Nitro Compounds
Norovirus / physiology*
Programmed Cell Death 1 Receptor / metabolism
Recurrence
Ribavirin / therapeutic use
Species Specificity
T-Lymphocytes / immunology*
Thiazoles / therapeutic use
Treatment Outcome
Up-Regulation

Substances

Antigens, CD19
Antiviral Agents
Nitro Compounds
PDCD1 protein, human
Programmed Cell Death 1 Receptor
Thiazoles
Ribavirin
nitazoxanide

Publication types

MeSH terms

Substances

Grants and funding