m5C Goes Viral

Shelby Winans; Karen Beemon

doi:10.1016/j.chom.2019.07.019

m⁵C Goes Viral

Cell Host Microbe. 2019 Aug 14;26(2):154-155. doi: 10.1016/j.chom.2019.07.019.

Authors

Shelby Winans¹, Karen Beemon²

Affiliations

¹ Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA.
² Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: klb@jhu.edu.

PMID: 31415745
DOI: 10.1016/j.chom.2019.07.019

Abstract

In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m⁵C than cellular mRNA. Deleting the m5C "writer" NSUN2 decreases HIV-1 m⁵C levels, promotes translation of the HIV-1 5' gag gene, and alters splicing at the A2 site.

Publication types

Comment

MeSH terms

Animals
HIV-1 / genetics*
Leukemia Virus, Murine
Methylation
Mice
RNA Splicing
RNA, Viral*

Substances

RNA, Viral

Grants and funding

S10 OD021567/OD/NIH HHS/United States