Lipid Droplets Grease Enterovirus Replication

George A Belov; Frank J M van Kuppeveld

doi:10.1016/j.chom.2019.07.017

Lipid Droplets Grease Enterovirus Replication

Cell Host Microbe. 2019 Aug 14;26(2):149-151. doi: 10.1016/j.chom.2019.07.017.

Authors

George A Belov¹, Frank J M van Kuppeveld²

Affiliations

¹ Department of Veterinary Medicine, University of Maryland, and VA-MD College of Veterinary Medicine, College Park, MD 20742, USA. Electronic address: gbelov@umd.edu.
² Division of Virology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address: f.j.m.vankuppeveld@uu.nl.

Abstract

Replication complexes of (+)RNA viruses of eukaryotes are associated with specialized membranous domains, termed replication organelles. How these structures develop is poorly understood. In a recent Cell paper, Laufman et al. (2019) reveal that enteroviruses recruit lipid droplets to support lipid synthesis required for the structural development of replication organelles.

Publication types

Comment

MeSH terms

Enterovirus Infections*
Enterovirus*
Humans
Lipid Droplets
Lipids
Virus Replication

Substances

Lipids

Grants and funding

R01 AI125561/AI/NIAID NIH HHS/United States