Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)8]12- (M = SnIV, PbIV)

Peng Yang; Tian Ma; Zhongling Lang; Sonja Misirlic-Dencic; Andjelka M Isakovic; Attila Bényei; Mirjana B Čolović; Ivanka Markovic; Danijela Z Krstić; Josep M Poblet; Zhengguo Lin; Ulrich Kortz

doi:10.1021/acs.inorgchem.9b01129

Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO₈Pd₁₂(PO₄)₈]^12- (M = Sn^IV, Pb^IV)

Inorg Chem. 2019 Sep 3;58(17):11294-11299. doi: 10.1021/acs.inorgchem.9b01129. Epub 2019 Aug 14.

Affiliations

¹ Department of Life Sciences and Chemistry , Jacobs University , Campus Ring 1 , 28759 Bremen , Germany.
² Departament de Química Física i Inorgànica , Universitat Rovira i Virgili , c/Marcel·lí Domingo 1 , 43007 Tarragona , Spain.
³ University of Debrecen , Department of Physical Chemistry , Egyetem tér 1 , 4032 Debrecen , Hungary.
⁴ Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry and Chemical Engineering , Beijing Institute of Technology , Beijing 100081 , P.R. China.

PMID: 31411862
DOI: 10.1021/acs.inorgchem.9b01129

Abstract

The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO₈Pd₁₂(PO₄)₈]^12- (M = Sn^IV, Pb^IV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Death / drug effects
Cell Proliferation / drug effects
Crystallography, X-Ray
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Ions / chemistry
Metals, Heavy / chemistry*
Models, Molecular
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Polymers / chemistry*

Substances

Antineoplastic Agents
Ions
Metals, Heavy
Organometallic Compounds
Polymers