Macitentan in the treatment of severe digital ulcers

Tatiana Gonçalves; Lèlita Santos

doi:10.1136/bcr-2018-228295

Macitentan in the treatment of severe digital ulcers

BMJ Case Rep. 2019 Aug 12;12(8):e228295. doi: 10.1136/bcr-2018-228295.

Authors

Tatiana Gonçalves^{1

2}, Lèlita Santos^{1

2

3}

Affiliations

¹ Internal Medicine Service, Coimbra Hospital and University Centre, Coimbra, Portugal.
² Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
³ CIMAGO Research Centre, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Abstract

Digital ulcers are one of the earliest and most disabling manifestations of systemic sclerosis (SSc). We report the clinical case of a female patient with SSc and severe digital ulcers, recurrent and refractory to the classic treatments to whom it was prescribed off-label macitentan with complete resolution of the condition.

Keywords: connective tissue disease; musculoskeletal and joint disorders; musculoskeletal syndromes; skin; therapeutic indications.

Publication types

Case Reports

MeSH terms

Aged
Female
Fingers / pathology
Humans
Pyrimidines / therapeutic use*
Scleroderma, Systemic / complications*
Skin Ulcer / drug therapy*
Skin Ulcer / pathology
Sulfonamides / therapeutic use*

Substances

Pyrimidines
Sulfonamides
macitentan