Evaluation of an alkali-treated and hydroxyapatite-coated orthopedic implant loaded with tobramycin

J Biomater Appl. 2019 Nov;34(5):699-720. doi: 10.1177/0885328219867968. Epub 2019 Aug 13.
No abstract available

Keywords: Hydroxyapatite; antibacterial; fixation screw; orthopedic implant; tobramycin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkalies / chemistry*
  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Biomechanical Phenomena
  • Bone Screws*
  • Cell Adhesion / drug effects
  • Cell Proliferation / drug effects
  • Coated Materials, Biocompatible / chemistry*
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Durapatite / chemistry*
  • Endothelial Cells / metabolism
  • Femur / surgery
  • Humans
  • Male
  • Osteoblasts / cytology
  • Prostheses and Implants
  • Rabbits
  • Staphylococcus aureus / drug effects
  • Surface Properties
  • Titanium / chemistry
  • Tobramycin / chemistry*
  • Tobramycin / pharmacology

Substances

  • Alkalies
  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Drug Carriers
  • Durapatite
  • Titanium
  • Tobramycin