Abstract
RNA represents an extremely promising and yet challenging therapeutic target. Here, we report the design of a series of C-nucleosides as original RNA binders. Some of them bind strongly and selectively to A-site prokaryotic ribosomal RNA.
MeSH terms
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Circular Dichroism
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Nuclear Magnetic Resonance, Biomolecular
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Nucleic Acid Conformation
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Nucleosides / chemistry
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Nucleosides / metabolism*
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RNA, Ribosomal / chemistry
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RNA, Ribosomal / metabolism*
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Ribosomes / metabolism*
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Thermodynamics
Substances
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Nucleosides
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RNA, Ribosomal