Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA

Chem Commun (Camb). 2019 Aug 27;55(70):10432-10435. doi: 10.1039/c9cc04915k.

Abstract

RNA represents an extremely promising and yet challenging therapeutic target. Here, we report the design of a series of C-nucleosides as original RNA binders. Some of them bind strongly and selectively to A-site prokaryotic ribosomal RNA.

MeSH terms

  • Circular Dichroism
  • Nuclear Magnetic Resonance, Biomolecular
  • Nucleic Acid Conformation
  • Nucleosides / chemistry
  • Nucleosides / metabolism*
  • RNA, Ribosomal / chemistry
  • RNA, Ribosomal / metabolism*
  • Ribosomes / metabolism*
  • Thermodynamics

Substances

  • Nucleosides
  • RNA, Ribosomal