Abstract
Before the development of the first vaccine, infectious diseases were a major cause of death around the globe with life expectancy estimated to be <50 years. Three measures have helped to drastically reduce the burden of infectious diseases but only vaccines have proven to be able to eradicate infectious agents. Herein, we describe new methodologies that have paved the way for what is currently known as modern vaccinology and the use of vaccines to tackle antimicrobial resistance, the biggest global threat of our time.
Keywords:
antimicrobial resistance (AMR); infectious diseases; vaccine development; vaccines; vaccinology.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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AIDS Vaccines
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Antibodies, Monoclonal / biosynthesis
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Antibodies, Monoclonal / immunology
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Neutralizing / immunology
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Antigens / genetics
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Antigens / immunology
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B-Lymphocytes / immunology
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Clinical Trials as Topic
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Communicable Diseases, Emerging / therapy*
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Disease Outbreaks / history
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Drug Resistance, Microbial
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Genetic Engineering
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Global Health
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History, 19th Century
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History, 20th Century
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History, 21st Century
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History, Ancient
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History, Medieval
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Immunotherapy, Active / history*
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Respiratory Syncytial Virus Vaccines
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Single-Cell Analysis
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Vaccination / history*
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Vaccines / history*
Substances
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AIDS Vaccines
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Antibodies, Monoclonal
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Antibodies, Neutralizing
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Antigens
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Respiratory Syncytial Virus Vaccines
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Vaccines