Huntington's Disease: Astrocytes Shift to Fatty Acid Metabolism

Trends Endocrinol Metab. 2019 Sep;30(9):575-577. doi: 10.1016/j.tem.2019.07.019. Epub 2019 Aug 6.

Abstract

A recent study by Polyzos et al. (Cell Metab., 2019) shows that astrocytes in a Huntington disease (HD) mouse model switch from glycolysis to fatty acid oxidation (FAO), causing increased superoxide radical anion production and loss of succinate dehydrogenase (SD) activity. Blocking mitochondria reactive oxygen species (ROS) with an antioxidant compound called XJB-5-151 reversed lipofuscin formation and protected the mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Antioxidants
  • Astrocytes
  • Huntington Disease*
  • Mice
  • Mitochondria
  • Neurons
  • Reactive Oxygen Species

Substances

  • Antioxidants
  • Reactive Oxygen Species