Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix

Hai-Bo Li; Ying Shi; Qianqian Pang; Yudan Mei; Zhenzhen Su; Xin-Sheng Yao; Yang Yu

doi:10.1016/j.fitote.2019.104290

Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix

Fitoterapia. 2019 Oct:138:104290. doi: 10.1016/j.fitote.2019.104290. Epub 2019 Aug 6.

Authors

Hai-Bo Li¹, Ying Shi¹, Qianqian Pang¹, Yudan Mei¹, Zhenzhen Su², Xin-Sheng Yao³, Yang Yu⁴

Affiliations

¹ Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China.
² Kanion Pharmaceutical Co. Ltd., State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China.
³ Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address: tyaoxs@jnu.edu.cn.
⁴ Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address: 1018yuyang@jnu.edu.cn.

PMID: 31398448
DOI: 10.1016/j.fitote.2019.104290

Abstract

Six new monoterpene glycosides, named 6'-O-nicotinoylalbiflorin (1), 4'-O-vanillylalbiflorin (2), paeonidanin L (3), paeoniflorigenin-1-O-β-d-xyloside (4), 6'-(2-hydroxypropanoyl)-paeoniflorin (5), oxylactiflorin (6), together with 16known ones (7-22) were isolated from the 70% ethanol extract of Paeoniae Radix. Their structures were elucidated based on spectroscopic analysis (1D and 2D NMR, HRESIMS, IR and UV), chemical evidences and comparison with literatures. The inhibitory effects of all the isolates were evaluated against lipopolysaccharide (LPS) stimulated PGE₂ production in RAW 264.7 macrophages.

Keywords: Anti-inflammatory; Monoterpene glycosides; PGE(2); Paeoniae Radix.

MeSH terms

Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
China
Drugs, Chinese Herbal / pharmacology
Glycosides / isolation & purification
Glycosides / pharmacology*
Mice
Molecular Structure
Monoterpenes / isolation & purification
Monoterpenes / pharmacology*
Paeonia / chemistry*
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Roots / chemistry*
RAW 264.7 Cells

Substances

Anti-Inflammatory Agents
Drugs, Chinese Herbal
Glycosides
Monoterpenes
Phytochemicals