Chlamydia spp. infections cause immunopathology of the male and female urogenital tracts and incidence continues to rise across the globe. Animal models offer the opportunity to study the host: pathogen relationship, with rodent models being an attractive first step in studying immune interactions, genetic knockout, as well as bacterial inhibitor and vaccine trials. Here we describe the methodology to infect both male and female rodents at various mucosal sites, with a particular focus on the reproductive tracts.
Keywords: Chlamydia caviae; Chlamydia muridarum; Chlamydia trachomatis; Reproductive tract; Urogenital tract.