Prenatal evaluation of the Sakoda complex

Pediatr Radiol. 2019 Dec;49(13):1843-1847. doi: 10.1007/s00247-019-04491-5. Epub 2019 Aug 5.

Abstract

Sakoda complex is a rare but distinct combination of birth defects consisting of a basal cephalocele, agenesis of the corpus callosum, and midline cleft lip/palate. It has been reported in association with ophthalmologic abnormalities, cognitive deficits and severe epilepsy. Here we describe both prenatal and postnatal MRI findings of a classic case of Sakoda complex in a child with characteristic findings on fetal MRI; prenatal findings have not been described in the literature. Diagnosis of this entity has important implications for prenatal counseling and perinatal management, as is demonstrated in this case.

Keywords: Basal encephalocele; Fetus; Magnetic resonance imaging; Neonate; Sakoda complex.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / diagnostic imaging*
  • Abnormalities, Multiple / therapy
  • Adult
  • Agenesis of Corpus Callosum / diagnostic imaging*
  • Cleft Lip / diagnostic imaging*
  • Cleft Palate / diagnostic imaging*
  • Congenital Abnormalities / diagnostic imaging
  • Encephalocele / diagnostic imaging*
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Meningocele / diagnostic imaging*
  • Pregnancy
  • Pregnancy Outcome*
  • Prenatal Diagnosis / methods
  • Rare Diseases
  • Ultrasonography, Prenatal / methods*

Supplementary concepts

  • Sakoda Complex