Rewiring regulatory T cells for tumour killing

Tomasz Maj; Weiping Zou

doi:10.1038/s41551-019-0443-y

Rewiring regulatory T cells for tumour killing

Nat Biomed Eng. 2019 Oct;3(10):766-767. doi: 10.1038/s41551-019-0443-y.

Authors

Tomasz Maj¹, Weiping Zou²

Affiliations

¹ Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
² Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. wzou@med.umich.edu.

Abstract

In mouse models of cancer, the inhibition of a set of regulatory proteins improves checkpoint-blockade therapy by causing regulatory T cells to produce the cytokine interferon-γ.

MeSH terms

Animals
B7-H1 Antigen / metabolism
CARD Signaling Adaptor Proteins / genetics
Cytokines / metabolism
Disease Models, Animal
Forkhead Transcription Factors / genetics
Histocompatibility Antigens Class I
Humans
Interferon-gamma / metabolism*
Lymph Nodes
Male
Mice
Mice, Knockout
Neoplasms / immunology*
Phenotype
T-Lymphocytes / metabolism*
T-Lymphocytes, Regulatory / immunology*
Thymus Gland

Substances

B7-H1 Antigen
CARD Signaling Adaptor Proteins
Card11 protein, mouse
Cd274 protein, mouse
Cytokines
Forkhead Transcription Factors
Foxp3 protein, mouse
Histocompatibility Antigens Class I
Interferon-gamma

Grants and funding

R01 CA190176/CA/NCI NIH HHS/United States