Data showing atherosclerosis-associated differentially methylated regions are often at enhancers

Michelle Lacey; Carl Baribault; Kenneth C Ehrlich; Melanie Ehrlich

doi:10.1016/j.dib.2019.103812

Data showing atherosclerosis-associated differentially methylated regions are often at enhancers

Data Brief. 2019 Mar 7:23:103812. doi: 10.1016/j.dib.2019.103812. eCollection 2019 Apr.

Authors

Michelle Lacey^{1

2}, Carl Baribault¹, Kenneth C Ehrlich³, Melanie Ehrlich^{1

3

4}

Affiliations

¹ Tulane Cancer Center, Tulane University Health Sciences Center, LA 70112, USA.
² Department of Mathematics, Tulane University, New Orleans, LA 70118, USA.
³ Center for Bioinformatics and Genomics, Tulane University Health Sciences Center, USA.
⁴ Hayward Genetics Center, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.

Abstract

Atherosclerosis involves phenotypic modulation and transdifferentiation of vascular smooth muscle cells (SMCs). Data are given in tabular or figure format that illustrate genome-wide DNA methylation alterations in atherosclerotic vs. control aorta (athero DMRs). Data based upon publicly available chromatin state profiles are also shown for normal aorta, monocyte, and skeletal muscle tissue-specific DMRs and for aorta-specific chromatin features (enhancer chromatin, promoter chromatin, repressed chromatin, actively transcribed chromatin). Athero hypomethylated and hypermethylated DMRs as well as epigenetic and transcription profiles are described for the following genes: ACTA2, MYH10, MYH11 (SMC-associated genes); SMAD3 (a signaling gene for SMCs and other cell types); CD79B and SH3BP2 (leukocyte-associated genes); and TBX20 and genes in the HOXA, HOXB, HOXC, and HOXD clusters (T-box and homeobox developmental genes). The data reveal strong correlations between athero hypermethylated DMRs and regions of enhancer chromatin in aorta, which are discussed in the linked research article "Atherosclerosis-associated differentially methylated regions can reflect the disease phenotype and are often at enhancers" (M. Lacey et al., 2019).

Keywords: Atherosclerosis; DMR, differentially methylated region; DNA methylation; Differentially methylated regions (DMRs); Enhancers; GO, gene ontology; Monocytes; PBMC, peripheral blood mononuclear cells; PMD, percent methylation difference; SkM, skeletal muscle; Smooth muscle; athero hypermeth DMR, atherosclerosis-associated hypermethylated DMR; athero hypometh DMR, atherosclerosis-associated hypomethylated DMR; ctl, control; enh, enhancer chromatin; mod, moderate; prom, promoter chromatin; repr, repressed; txn chromatin, chromatin with the histone marks of actively transcribed chromatin.

Grants and funding

UL1 TR001417/TR/NCATS NIH HHS/United States