Thyroid disease and the metabolic syndrome

Curr Opin Endocrinol Diabetes Obes. 2019 Oct;26(5):256-265. doi: 10.1097/MED.0000000000000500.

Abstract

Purpose of review: To summarize recent developments in the association of thyroid function with metabolic syndrome (MetS).

Recent findings: Although thyroid hormones even within low normal range are associated with various metabolic abnormalities, the risk of MetS remains a controversial issue. Hyperthyroid state might be associated only with insulin resistance and dysglycemia. Autoimmune thyroid diseases may be a potential risk factor for metabolic abnormalities even in those with low normal thyroid function.

Summary: The interrelation between thyroid stimulating hormone, free T3, freeT4 and metabolic parameters is complex and might be affected by age, sex, BMI, insulin resistance, smoking, iodine intake and inflammatory markers.

Publication types

  • Review

MeSH terms

  • Humans
  • Insulin Resistance
  • Metabolic Syndrome / etiology*
  • Thyroid Diseases / complications*
  • Thyroid Hormones / blood

Substances

  • Thyroid Hormones