Acute myeloid leukemia arising after Hodgkin lymphoma in a patient with WHIM syndrome

Pediatr Blood Cancer. 2019 Nov;66(11):e27951. doi: 10.1002/pbc.27951. Epub 2019 Jul 31.

Authors

Aoli Zhang^{1

2}, Xiaojuan Chen¹, Zhanqi Li¹, Min Ruan¹, YingChi Zhang¹, Xiaofan Zhu¹

Affiliations

¹ Department of Pediatric Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
² Department of Hematology, The Second Hospital of Shanxi Medical University, Shanxi, China.

PMID: 31368255
DOI: 10.1002/pbc.27951

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antimetabolites, Antineoplastic / administration & dosage
Antimetabolites, Antineoplastic / pharmacology
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cell Transformation, Neoplastic / genetics
Combined Modality Therapy
Core Binding Factor Alpha 2 Subunit / genetics
DNA (Cytosine-5-)-Methyltransferase 1 / antagonists & inhibitors
Dasatinib / administration & dosage
Dasatinib / pharmacology
Decitabine / administration & dosage
Decitabine / pharmacology
Female
Gain of Function Mutation
Hematopoietic Stem Cell Transplantation
Hodgkin Disease / drug therapy
Hodgkin Disease / genetics*
Hodgkin Disease / radiotherapy
Humans
Infant
Leukemia, Myeloid, Acute / genetics*
Molecular Targeted Therapy
Neoplasm Proteins / antagonists & inhibitors
Neoplasm Proteins / genetics
Neoplasms, Second Primary / genetics*
Neoplasms, Second Primary / therapy
Oncogene Proteins, Fusion / genetics
Primary Immunodeficiency Diseases / complications*
Proto-Oncogene Proteins c-kit / antagonists & inhibitors
Proto-Oncogene Proteins c-kit / genetics
RUNX1 Translocation Partner 1 Protein / genetics
Radiotherapy, Adjuvant
Receptors, CXCR4 / genetics
Remission Induction
Warts / complications*

Substances

AML1-ETO fusion protein, human
Antimetabolites, Antineoplastic
CXCR4 protein, human
Core Binding Factor Alpha 2 Subunit
Neoplasm Proteins
Oncogene Proteins, Fusion
RUNX1 Translocation Partner 1 Protein
Receptors, CXCR4
Decitabine
DNA (Cytosine-5-)-Methyltransferase 1
DNMT1 protein, human
KIT protein, human
Proto-Oncogene Proteins c-kit
Dasatinib

Supplementary concepts

WHIM syndrome