Retrospective investigation of IgM antibodies against Zika virus in serum from febrile patients in Mozambique, 2009-2015

BMC Res Notes. 2019 Jul 31;12(1):469. doi: 10.1186/s13104-019-4511-x.

Abstract

Objective: Zika virus (ZIKV) has emerged as an important health problem worldwide. The aim of this study was to investigate the occurrence, geographical distribution and trend of immunoglobulin M (IgM) antibodies against ZIKV between 2009 and 2015 in Mozambique.

Results: The median age of participants was 3 years [interquartile range (IQR): 1.0-6.0 years)] and 56.5% (480/850) of them were male. Of the 850 samples, 42 (4.9%) were positive for IgM antibodies against ZIKV. Positive samples were found in 9 provinces of the country. Frequency of IgM antibodies against ZIKV was slightly higher in patients aged 5-9 years old, and in the north region of the country.

Keywords: Febrile patient; Mozambique; Zika.

MeSH terms

  • Adolescent
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fever / diagnosis
  • Fever / epidemiology*
  • Fever / immunology
  • Fever / virology
  • Humans
  • Immunoglobulin M / blood*
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • Mozambique / epidemiology
  • Retrospective Studies
  • Zika Virus / immunology*
  • Zika Virus Infection / diagnosis
  • Zika Virus Infection / epidemiology*
  • Zika Virus Infection / immunology
  • Zika Virus Infection / virology

Substances

  • Antibodies, Viral
  • Immunoglobulin M