CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion

An Bras Dermatol. 2019 Jul 26;94(3):341-343. doi: 10.1590/abd1806-4841.20198789.

Abstract

CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with complete clearance of her CHILD nevus. The changes in skin lipid metabolism that explain the CHILD ichthyosiform nevus and their correction through topical application of cholesterol and lovastatin are discussed.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / drug therapy*
  • Abnormalities, Multiple / genetics
  • Administration, Topical
  • Anticholesteremic Agents / administration & dosage*
  • Cholesterol / biosynthesis
  • Cholesterol / metabolism*
  • Female
  • Genetic Diseases, X-Linked / drug therapy*
  • Genetic Diseases, X-Linked / genetics
  • Humans
  • Ichthyosiform Erythroderma, Congenital / drug therapy*
  • Ichthyosiform Erythroderma, Congenital / genetics
  • Infant
  • Limb Deformities, Congenital / drug therapy*
  • Limb Deformities, Congenital / genetics
  • Lovastatin / administration & dosage*
  • Metabolic Diseases / genetics

Substances

  • Anticholesteremic Agents
  • Cholesterol
  • Lovastatin

Supplementary concepts

  • Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects