Abstract
CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with complete clearance of her CHILD nevus. The changes in skin lipid metabolism that explain the CHILD ichthyosiform nevus and their correction through topical application of cholesterol and lovastatin are discussed.
MeSH terms
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Abnormalities, Multiple / drug therapy*
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Abnormalities, Multiple / genetics
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Administration, Topical
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Anticholesteremic Agents / administration & dosage*
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Cholesterol / biosynthesis
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Cholesterol / metabolism*
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Female
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Genetic Diseases, X-Linked / drug therapy*
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Genetic Diseases, X-Linked / genetics
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Humans
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Ichthyosiform Erythroderma, Congenital / drug therapy*
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Ichthyosiform Erythroderma, Congenital / genetics
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Infant
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Limb Deformities, Congenital / drug therapy*
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Limb Deformities, Congenital / genetics
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Lovastatin / administration & dosage*
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Metabolic Diseases / genetics
Substances
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Anticholesteremic Agents
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Cholesterol
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Lovastatin
Supplementary concepts
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Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects