[Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model]

Zhongguo Zhong Yao Za Zhi. 2019 Jul;44(13):2662-2666. doi: 10.19540/j.cnki.cjcmm.20190520.205.
[Article in Chinese]

Abstract

Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed. The results indicated that 1. 77 μmol·L-1 SSa showed protective effect to AFL zebrafish. 5. 30 μmol·L-1 SSa was hepatotoxic to healthy zebrafish,but it showed protective effect to AFL zebrafish. 5. 62 μmol·L-1 SSa was hepatotoxic to healthy and AFL zebrafish. This study is benefit for clinical safety of saikosaponin a.

Keywords: hepatotoxicity; liver protection; saikosaponin a; zebrafish.

MeSH terms

  • Animals
  • Chemical and Drug Induced Liver Injury*
  • Fatty Liver, Alcoholic / drug therapy*
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / pharmacology
  • Oleanolic Acid / toxicity
  • Saponins / pharmacology*
  • Saponins / toxicity*
  • Zebrafish

Substances

  • Saponins
  • Oleanolic Acid
  • saikosaponin D