Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2

Mohamed A Eldeeb; Emma J MacDougall; Mohamed A Ragheb; Edward A Fon

doi:10.1016/j.tcb.2019.07.003

Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2

Trends Cell Biol. 2019 Sep;29(9):687-689. doi: 10.1016/j.tcb.2019.07.003. Epub 2019 Jul 26.

Authors

Mohamed A Eldeeb¹, Emma J MacDougall², Mohamed A Ragheb³, Edward A Fon⁴

Affiliations

¹ McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Electronic address: Mohamed.eldeeb@mcgill.ca.
² McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
³ Chemistry Department (Biochemistry Division), Faculty of Science, Cairo University, Giza, Egypt.
⁴ McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Electronic address: ted.fon@mcgill.ca.

PMID: 31358413
DOI: 10.1016/j.tcb.2019.07.003

Abstract

Despite the progress in understanding the molecular responses to mitochondrial damage, responses to aberrant accumulation of mitochondrial precursor proteins and mitochondrial import defects remain poorly understood. Recent work (Mårtensson et al., Nature, 2019) has unveiled a pathway similar to endoplasmic-reticulum-associated degradation (ERAD) in fine-tuning the fidelity of translocase of the outer mitochondrial membrane (TOM) complex-mediated mitochondrial import.

Keywords: TOM complex; mitochondrial import; mitochondrial quality control; proteasome; protein degradation; protein quality control; ubiquitin.

Publication types

Review

MeSH terms

Carrier Proteins / metabolism*
Endoplasmic Reticulum-Associated Degradation
Mitochondrial Membrane Transport Proteins / metabolism
Mitochondrial Membranes / metabolism*
Mitochondrial Precursor Protein Import Complex Proteins
Mitochondrial Proteins / metabolism*
Protein Transport
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / metabolism*

Substances

Carrier Proteins
Mitochondrial Membrane Transport Proteins
Mitochondrial Precursor Protein Import Complex Proteins
Mitochondrial Proteins
Saccharomyces cerevisiae Proteins
UBX2 protein, S cerevisiae