The diversity of pattern recognition receptors (PRRs) involved with insect defense against pathogens

Abstract

Through evolution, selection pressures cause both insects and the pathogens attacking them to adapt so that they will both survive and this has been called the co-evolutionary 'arms race'. Insects expand their repertoire of pattern recognition receptors (PRRs), a fundamental and core component of their immune systems, to adapt to the constantly changing and unpredictable diversity of pathogens. In this review, we discuss the diversity of PRRs based on studies conducted in recent years. The strategies associated with PRR diversity summarized here are genetic evolution, isoform diversity based on alternative splicing, 'part-time' PRRs, PRRs with opsonin function, and regulation of complex signaling pathways. Taken together, these data indicate that the function of PRRs in insect immunity is far more complex and possesses more features than originally thought.