Polyurethane tissue adhesives for annulus fibrosus repair: Mechanical restoration and cytotoxicity

Lucas Dall Agnol; Fernanda Trindade Gonzalez Dias; Natália Fontana Nicoletti; Daniel Marinowic; Sidnei Moura E Silva; Angel Marcos-Fernandez; Asdrubal Falavigna; Otávio Bianchi

doi:10.1177/0885328219864901

Polyurethane tissue adhesives for annulus fibrosus repair: Mechanical restoration and cytotoxicity

J Biomater Appl. 2019 Nov;34(5):673-686. doi: 10.1177/0885328219864901. Epub 2019 Jul 27.

Authors

Affiliations

¹ 1 Health Sciences Graduate Program, University of Caxias do Sul (UCS), Caxias do Sul, RS, Brazil.
² 2 Materials Science Graduate Program (PGMAT), University of Caxias do Sul (UCS), Caxias do Sul, RS, Brazil.
³ 3 Cell Therapy Laboratory (LATEC), University of Caxias do Sul (UCS), Caxias do Sul, Brazil.
⁴ 4 Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
⁵ 5 Laboratory of Biotechnology of Natural and Synthetics Products, Technology Department, Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, RS, Brazil.
⁶ 6 Instituto de Ciencia y Tecnología de Polímeros (CSIC), Madrid, Spain.
⁷ 7 Federal University of Rio Grande do Sul, Materials engineering department, Porto Alegre, Brazil.

PMID: 31354030
DOI: 10.1177/0885328219864901

No abstract available

Keywords: Urethane adhesive; annulus fibrosus repair; injectable sealant; kinetic predictions; mechanical viability; reactivity with collagen tissue.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Annulus Fibrosus / metabolism*
Cell Line
Cell Survival / drug effects
Coated Materials, Biocompatible / administration & dosage
Coated Materials, Biocompatible / chemical synthesis*
Coated Materials, Biocompatible / metabolism
Collagen / chemistry
Haplorhini
Injections
Kinetics
Mechanical Phenomena
Mice
Polycarboxylate Cement / chemistry
Polyurethanes / administration & dosage
Polyurethanes / chemical synthesis*
Polyurethanes / metabolism
Surface Properties
Temperature
Thermodynamics
Tissue Adhesions / metabolism
Tissue Adhesives / administration & dosage
Tissue Adhesives / chemical synthesis*
Tissue Adhesives / metabolism
Viscosity

Substances

Coated Materials, Biocompatible
Polycarboxylate Cement
Polyurethanes
Tissue Adhesives
polycarbonate
Collagen